When a patient with defective ADA was treated, which of the…

Biology Biotechnology and Its Application Statement Based Questions Single Correct MCQ

Published by: CGP EDU Academic Team

Published on: August 21, 2026

When a patient with defective ADA was treated, which of the following steps was performed for gene therapy?

(i) Lymphocytes were obtained from the patients.

(ii) Lymphocytes are transferred to culture dishes.

(iii) Lymphocytes were transfected with normal ADA genes.

(iv) The transfected cells are returned to the patients.

All of these

(iii) and (iv)

Only (iv)

SCID cannot be treated

Text Solution

Verified by Experts

The correct answer is:

Gene therapy for ADA deficiency (SCID) involves ex vivo correction:

(i) Correct → Lymphocytes are isolated from patient’s blood.

(ii) Correct → These lymphocytes are cultured in laboratory.

(iii) Correct → Normal ADA gene is introduced into cells using vectors.

(iv) Correct → Modified cells are reinfused into patient’s body.

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